鹼式醋酸鋁的合成與氯化鋁的緩釋劑型的開發

Chaoyang University of Technology Institutional Repository > 理工學院 > 應用化學系 > 博碩士論文 > Item 310901800/27612

Please use this identifier to cite or link to this item: http://ir.lib.cyut.edu.tw:8080/handle/310901800/27612

Title:	鹼式醋酸鋁的合成與氯化鋁的緩釋劑型的開發 The synthesis of basic aluminum acetate and development of sustained-released aluminum chloride
Authors:	黃致誠 Huang, Jr-Cheng
Contributors:	應用化學系碩士班許世興 Ce-shing Sheu
Keywords:	鹼式醋酸鋁;氯化鋁;緩釋劑型 basic aluminum acetate;aluminum chloride
Date:	2006-12-31
Issue Date:	2016-01-13 11:06:27 (UTC+8)
Abstract:	利用Sodium Aluminate與Acetic acid經過低速攪拌反應，再經由重複的水洗與抽氣過濾，順利合成出Aluminum diacetate，產率約為67.3%。在成份的分析探討上，利用與市售的四種不同公司的Aluminum acetate來做比較，比較自製的藥品與市售藥品的接近程度與差異性，由分析結果顯示，在每克樣品含鋁元素含量百分比方面自製藥品為14.8%其他市售的含量分別介於13.5%~16.4%之間，鈉元素的殘留量方面自製藥品為240.8ppm其他市售的濃度分別介於109.6 ppm~312.8 ppm之間。進一步再研發氯化鋁運用在緩釋劑型上，利用流動噴霧造粒乾燥機(fluid-bed spray/granulator/coater)，將氯化鋁包覆於Polymethacrylate中，經過配方與多次試驗最後選擇Eudragit S 型來當作包覆膠體，塑化劑的選擇為Citroflex-2(triethyl 2-hydroxypropane-1,2,3- tricarboxylate) ，塑化劑濃度的選擇最後決定為佔整體包覆膜約15%的濃度添加於solution中，此時有最好的韌性與不易脆弱的特性。包覆濃度的比例選擇，為每克的氯化鋁含有30%的Eudragit S 100 。 As sodium meta aluminate and acetic acid were mixed at a low speed until reaction was completed, the resulting mixture was filtered with suction along with a thorough washing. The product of aluminum diacetate was obtained in 67.3% of yield.We make a composition analysis of Aluminum acetate from four different companies in the market. We compare the difference which is between self-made composition and other companies compositions. The result of an analysis about aluminum concentration is that self-made composition is 14.8% but the composition of the companies is between 13.5~16.4%; the result of an analysis about sodium residual is that self-made composition is 240.8ppm and the other is between 109.6ppm~312.8ppm.Furthermore, we use fluid-bed spray/granulator/coater to make aluminum chloride coating with Polymethacrylate. After many experiments we make a conclusion. The first is we choose Eudragit S to be coating. The second is that the plasticizer is Citroflex-2. The third is that the choice of plasticizer concentration is added about 15% of Eudragit S into solution. At this time, it is the best ductility and unfriability. The percentage of coating concentration is 30% Eudragit S in per gram aluminum chloride.
Appears in Collections:	[應用化學系] 博碩士論文

Files in This Item:

File	Size	Format
094CYUT5500005-001.zip	629Kb	Unknown	71	View/Open

Loading...